The Hebrew University of Jerusalem


Dr. Julia Shifman
The Protein Design Lab
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Lab News

Aug 30 2014

Noa Oppenheimer joins the lab as B.Sc. Student

Dec 19 2013

Congratulations to Adina for finishing her M.Sc.

Nov 15 2013 Congratulations to Oz for finishing his  Ph.D.

Oct 9 2013

Michael Heyne joins the lab as Ph.D. Student



We use very fast computational algorithms to search through an astronomical number of possible amino acid sequences and to obtain the optimal sequence for a particular protein scaffold. Computationally predicted sequences are constructed experimentally and assayed for the desired properties. Experimental results are fed back into the computational algorithm, completing the protein design cycle. We are particularly interested in applying protein design to studying protein-protein interactions and modifying protein binding affinity and specificity. The nature of our research allows us to work closely with hard-core theorists whose simple models of protein folding and design offer clear insights into protein behavior. At the same time, we collaborate with experimental biologists providing them with computational means to study various biological systems. 

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