Cell & Developmental Biology

The Department of Cell and Developmental Biology carries out research and teaching on a broad spectrum of biological levels ranging from the molecule, cell, organ and system to the intact organism. The unifying research question of our department is how molecular and cellular mechanisms serve larger scale, integrative functions, such as the development and physiology of tissues and organ systems, sensation and behavior. This interdisciplinary approach is served by faculty members whose individual specialties span developmental biology, cell and tumor biology, epigenetics, physiology, endocrinology, neuroscience and tissue engineering. Research in the department aims at elucidating mechanisms involved in cancer, Parkinson’s disease, Alzheimer’s disease, chronic pain, gastrointestinal infections and lipid metabolism. Although most of the department's work is defined as basic science, some applied research is also carried out. Examples of such projects are the development of novel analgesic drugs, biomaterials (e.g. spider silk), artificial organs, differentiation factors, and treatment of diseases such as diabetes, obesity, HCV infection and atherosclerosis.

E-mail Phone Fax Office
Prof. Aroeti Prof. Benjamin Aroeti
Head of Department
02-65-85915 02-6584547 Silberman 3-519
Dr. Amir Eden Dr. Amir Eden
Head of Graduate Program
02-65-84981 Silberman -564
Ms. Miriam Revivo
Head of Secretariat
02-65-85100 02-6586296
Ms. Avital Ben-Simon
Secretariat Staff
02-65-86530 Silberman 3-4XX
Prof. Aroeti in his lab
Cell Biology of Infectious Diseases
Membrane traffic in health and disease (endocytosis, exocytosis, transcytosis); Membrane domains; Epithelial cell polarity; Cell biology of enteric bacterial pathogens; Pathogenic bacteria – epithelial host interactions; Inflammatory bowel diseases (Crohn’s disease, ulcerative colitis) 
Preparing samples
Genetic Regulation of CNS Development & Neurodegenerative Diseases
Developmental Neuro-Genetics: the study of bHLH transcription factors regulating embryonic development, focusing on the nervous system. Characterization of the role and function of the transcription factors at the cellular and whole organism levels, utilizing chick embryos and knockout and transgenic mice. Revealing their molecular mode of action at various levels (transcription regulation of target genes, molecular interactions: DNA-protein, protein-protein etc.). We also study the involvement of transcription factors in human diseases (developmental, inherited and cancer).
Dr. Amnon Buxboim in his lab
Mechanobiology of Stem Cells and Nucleus
Biophysics Cell-matrix interactions in directing cell-fate decision making, Remodeling of the nuclear matrix of lamins and chromatin
Prof. Camhi
Neuroethology of Insects
My main research concerns neuroethology of insects, with special emphasis on the escape system of the cockroach. More recently, my research has been in the area of museology, focusing on educational methods for improving the impact of guided tours at nature museums.
Prof. Devor in his lab
Pain & Anesthesia Research Laboratory
Plasticity in the somatosensory system in mammals. Neural mechanisms whereby injury provokes sensory dysfunction and chronic pain. Pathophysiology of injured nerve and abnormal impulse generation. Synaptic reorganization in the brain and spinal cord after peripheral nerve injury. Regeneration and collateral sprouting of injured nerve fibers. Animal models of chronic pain states and pain relief. Heritability of chronic pain. Neural mechanisms of loss of pain response and of consciousness in general anesthesia.
Dr. Eden in his lab
Epigenetics, Chromatin & Cancer
Epigenetic regulation of gene expression. Cancer epigenetics.
The hair follicle as a model for organogesis
The Hair Follicle as a Model for Organogenesis
The role of Runx factors in the development of hair and other skin appendages; Molecular control of the hair keratin genes in mouse and man; The spider silk proteins – structure and function in fiber formation; Synthesis of recombinant spider silk fibers as novel biomaterials.
Cell Biology of Malignant Cells
The relation between cell adhesiveness and growth control in malignant lymphoma cells. Molecular mechanisms involved in the selection of non-malignant variant cells from malignant cell populations. Different approaches to reversal of multi-drug resistance of malignant cells. Growth regulation of malignant lymphoma. Metastasis of malignant lymphoma.
Prof. Mitrani in his lab
Tissue Engineering
Genes coding for factors involved in control of differentiation and development. Control of proliferation and differentiation in adult tissues. Epithelial mesenchymal interactions. Gene therapy, angiogenesis, ageing. Differentiation of stem cells. Cell therapy.
Professor Nahmias Yaakov's lab
Liver Tissue Engineering & Metabolism
1. Metabolic programing: nuclear reactors-based control of metabolism 2. Human embryonic stem cell differentiation to hepatocytes 3. Liver tissue engineering and liver regeneration 4. Hepatitis C Virus (HCV) infection
Different appearances of locust
Insect Physiology
Density-dependent phase polymorphism of locusts and the endocrine relations of such phase polymorphism. Interrelations between environmental physiology, neurohormones, diapause and life-cycle strategies of insects. Taxonomy, bionomics and general biology of grasshoppers (Tettigoniidae and Acrididae). Insect growth disruptors and Allergy to locusts.
Research model
RNA Regulation of Early Zebrafish Embryogenesis
We use the zebrafish embryo as an in-vivo model to study RNA biology of vertebrate development. Changes in the RNA content of embryonic pluripotent cells lead them to assume more specialized identities. Large efforts strive to understand how the ‘birth’ of RNA (transcription) direct developmental changes, but less is known about the regulation of RNA after its production: during RNA splicing, localization, and ‘death’ by degradation. The zebrafish embryo provides important research advantages in easy manipulations through microinjection, large numbers of embryos and powerful imaging tools within optically transparent embryos. 


מועד ומיקום Info
Tuesday, June 25, 2019 - 12:00

Faculty Club, Silberman Bldg.
Speaker: Prof. Tal Burstyn-Cohen,Institute for Dental Sciences, Faculty of Dental Medicine, The Hebrew University of Jerusalem
Title: Tumor-microenvironment interactions:Two opposing functions for one Protein S
Tuesday, June 18, 2019 - 12:00

Faculty Club, Silberman Bldg.
Speaker: Rachana P Ramachandran, Prof. Aroeti's lab
Title: Enteropathogenic E.coli modulates MAP-Kinase signaling to promote infection of the human intestines
Tuesday, June 11, 2019 - 12:00

Faculty Club, Silberman Bldg.
Speaker: Prof. Oren Froy,ssociate Professor of Neuroendocrinology and Metabolism, Director of the Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem
Title: Timing of macronutrient intake:underlying mechanisms and endocrine outcomes
Tuesday, June 4, 2019 - 12:00

Faculty Club, Silberman Bldg.
Speaker: Dr. Smadar Ben Tabou De Leon ,Department of Marine Biology, the Charney School of Marine Sciences, University of Haifa 
Title: Possible co-option of a VEGF-driven tubulogenesis program for biomineralization in echinoderms
Tuesday, May 28, 2019 - 12:00

Faculty Club, Silberman Bldg.
Speaker: Prof. Ron Milo, Department of Plant & Environmental Sciences,Weizmann Institute
Title: Biomass distribution on Earth
Tuesday, May 14, 2019 - 12:00

Faculty Club, Silberman Bldg.
Speaker: Dr. Nissim Lior, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
Title: Synthetic gene circuits for cancer immunotherapy
Tuesday, April 30, 2019 - 12:00

Faculty Club, Silberman Bldg.
Speaker: Prof. Peleg Hasson,Laboratory of Tissue Development, The Ruth and Bruce Rappaport Faculty of Medicine, Technion
Title: Bridging the gap – the making of seamless junctions in the muscular system
Monday, April 29, 2019 - 10:00

Faculty Club, Silberman Bldg.
Speaker: Prof. Benny Elbaz,Department of Neurology, University of Chicago
Title: Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation
Tuesday, April 2, 2019 - 12:00

Faculty Club, Silberman Bldg.
Speaker: Dr. Ramon Birnbaum Department of Life Sciences, Ben Gurion University of the Negev
Title: The role of gene regulatory elements in human diseases
Tuesday, March 19, 2019 - 12:00

Faculty Club, Silberman Bldg.
Speaker: Prof. Lital Alfonta,Departments of Life Sciences and Chemistry and Ilse Katz Institute for Nanoscale science and technology,  Ben-Gurion University of the Negev
Title: Expansion of the Genetic code of redox enzymes and proteins in different microorganisms
Tuesday, March 12, 2019 - 12:00

Faculty club, Silberman bldg.
Speaker: Dr. Ronen Hazan,The Hebrew University, Hadassah School of Dental Medicine
Title: Phage therapy as a promising solution to the antibiotic resistance crisis
Tuesday, January 15, 2019 - 12:00

Faculty club, Silberman bldg.
Speaker: Dr. Dan Bracha, Department of Chemical and Biological Engineering, Princeton University 
Title: Optogenetic protein droplets: Mapping and moving through intracellular phase space 
Tuesday, January 8, 2019 - 12:00

Faculty club, Silberman bldg.
Speaker: Dr. Tali Ilovitsh, Department of Radiology, School of Medicine, Stanford University
Title: Medical ultrasound: advanced imaging  and targeted therapy


מועד ומיקום Info
Tuesday, November 20, 2018 - 12:00

Faculty club, Silberman bldg.
Speaker: Dr. Nitzan Gonen Stem Cell Biology & Developmental Genetics lab, The Francis Crick Institute, London, UK
Title: How to enhance sex?
Tuesday, November 13, 2018 - 12:00

Faculty club, Silberman bldg.
Speaker: Dr. Michael Klutstein, Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University of Jerusalem 
Title: Analysis of spermatogenesis using new molecular methods - Mouse today, human tomorrow? 
E-mail Phone Fax Office
Prof. Aroeti Prof. Benjamin Aroeti

02-65-85915 02-6584547 Silberman 3-519
Prof. Nissim Ben-Arie Prof. Nissim Ben-Arie

Research website
02-65-84283 02-6528039 Silberman 3-510
Ms. Avital Ben-Simon

02-65-86530 Silberman 3-4XX
Dr. Amnon Buxboim Dr. Amnon Buxboim

Research website
02-65-85951 02-5494605 Silberman -502
Prof. Emeritus Jeff Camhi Prof. (Emeritus) Jeff Camhi

Dr. Merav Cohen

02-65-85416 Silberman 3-5XX
Prof. Marshall Devor Prof. Marshall Devor

Research website
02-65-85085 Silberman -533
Dr. Amir Eden Dr. Amir Eden

Research website
02-65-84981 Silberman -564
Ms. Yelena Fishman

02-65-86436 Silberman 2-516
Dr. Uri Gat Dr. Uri Gat

Research website
02-65-85920 Silberman -576
Prof. Jacob Hochman Prof. (Emeritus) Jacob Hochman

02-65- Silberman 3-5XX
Dr. Anne Minert - Fatal

02-65-85895 Silberman 2-516
Prof. Eduardo Mitrani Prof. (Emeritus) Eduardo Mitrani

02-65-85925 Silberman -523
Professor Nahmias Yaakov Prof. Yaakov Nahmias

Research website
02-65-84406 02-6585418 Silberman -512
Prof. Meir Pener Prof. (Emeritus) Meir Paul Pener

02-65-85952 Silberman -528
Dr. Michal rabani Dr. Michal Rabani

Research website
02-65- Silberman 2-516
Ms. Miriam Revivo

02-65-85100 02-6586296
Ms. Efrat Zlotkin-Rivkin

02-65-85972 Silberman 3-5XX