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The Alexander Silberman Institute of Life Science
Adler Miri
Dr. Miri Adler
Universal Principles of Tissues in Health and Disease
Genetics
Personal Information
Research Interests
The tissues in our body are made up of different types of cells that communicate with each other to perform joint tasks. Tissues differ greatly from each other in the composition of the cells, spatial structure, and function.
- What are the principles that are universal across different tissues?
- What are the characteristics of the communication between cells that are critical to the normal functioning of the tissue?
- What diseases may develop if these characteristics are not maintained?
In our research we develop computational methods and mathematical models and analyze experimental data to discover the universal principles in intercellular communication that are essential for the proper functioning of the tissue.
Dissertation Topics
- Universal design principles of optimal division of labor in tissues.
- Cell-cell communication circuits for stability of cell ratios and proper cell hierarchy in tissues.
- Development of a computational method to infer and characterize the heterogeneous tissue environment without direct measurements of the cell microenvironment
- Principles of cell-cell communication circuits in wound healing and fibrotic diseases.
- Development of novel computational and theoretical methods to understand dynamics and structure of complex networks.
