To address a major challenge in aging research, the lack of short-lived vertebrate genetic model, I have developed a comprehensive genetic platform for rapid exploration of aging and disease in the shortest-lived vertebrate model, the African turquoise killifish.
This genome-to-phenotype platform includes a sequenced genome, CRISPR/Cas9-based genome editing, and mutant fish for many aging- and disease-relates genes.
Taking advantage of this exciting platform the we explore fundamental questions in biology, such as why is aging such a strong driver for disease? And what is the molecular basis behind the outstanding diversity of vertebrate lifespan (which can reach up to 1000-fold).
Experimental biology of vertebrate aging and age-related diseases using the short-lived African turquoise killifish; The genetic basis behind the outstanding diversity of lifespan between different animals; Genetic engineering and live imaging of age-related traits in multiple complex organs.