Our goal is to understand the regulatory role of the ribosome in the central dogma of gene expression.

We explore molecular mechanisms of translation-regulation, focusing on the role of RNA modifications in translational control during normal hematopoietic development, leukemia initiation, and viral infection.

 

In our studies we utilize many molecular techniques, such as ribosome profiling, RNA modification sequencing and CRISPR-based screens. We combine these with ex-vivo stem cell research and in-vivo models by bone marrow transplantation, and leukemia xenograft. Using this diverse tool box we aim to reveal the centrality of cell-type-specific translation for the establishment of cell identity.