Netanel Tzarum

Dr. Netanel Tzarum
Structural and Functional Studies of Hepaciviruses
Biological Chemistry

Research Interests

Hepatitis C virus (HCV) is a major health burden that infects 1-2% of the world population and leads to ~500,000 deaths and an estimated 1.5-2 million new infections annually.
Direct-acting antivirals effectively treat HCV infection, yet face major issues making the development of additional therapeutics and an effective vaccine critical to prevent HCV spread.
Our research objectives are:
  • To study the immune recognition neutralization of HCV by the adaptive immune system.
  • To explore the interactions between the HCV envelope proteins and the host cells receptors.
  • Structural elucidation of the entry mechanism of HCV and HCV-related hepaciviruses.
To achieve these objectives, we utilize structural (X-ray crystallography), biochemical and functional tools. A deep understanding of the interaction between HCV and the host cells and will be use to facilitate structural-based design of novel therapeutics and subunit vaccine immunogens for better controlling of HCV spread.

Dissertation Topics

  1. Structural studies of the immune recognition of Hepatitis C virus (HCV) to facilitate structural-based vaccine design. 
  2. Development of a small-scale expression and solubility screening system for viral envelope glycoprotein.
  3. Structural studies of the entry mechanism of HCV-related hepaciviruses.
  4. Structural and biochemical studies of the interactions between the HCV envelope glycoprotein and host cell receptors.
Dr. Netanel  Tzarum


Mobile Phone
Silberman 3-618