Netanel Tzarum

Dr. Netanel Tzarum
Structural and Functional Studies of Hepaciviruses
Biological Chemistry

Personal Information

Research Interests

Hepatitis C virus (HCV) is a major health burden that infects 1-2% of the world population and leads to ~500,000 deaths and an estimated 1.5-2 million new infections annually.
Direct-acting antivirals effectively treat HCV infection, yet face major issues making the development of additional therapeutics and an effective vaccine critical to prevent HCV spread.

Using structural, biochemical and functional tools we study the immune recognition of HCV and the entry mechanism of HCV-related hepaciviruses to facilitate structural-based design of novel therapeutics and subunit vaccine immunogens against HCV.

Dissertation Topics

  1. Structural studies of the immune recognition of Hepatitis C virus (HCV) to facilitate structural-based vaccine design. 
  2. Development of a small-scale expression and solubility screening system for viral envelope glycoprotein.
  3. Structural studies of the entry mechanism of HCV-related hepaciviruses.
  4. Structural and biochemical studies of the interactions between the HCV envelope glycoprotein and host cell receptors.
 
Dr. Netanel  Tzarum

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Silberman