The following bus lines reach the Edmond J. Safra Campus:
- From the central bus station: lines 14, 66 , 66A , 68.
- From the city center: lines 7, 7A (from the Nachlaot), line 9 (from Rechavia)
- From Ein-Kerem campus: line 42
- From Malcha mall: lines 35, 35A (descend at Bitiach-Leumi bus stop and walk ~5 minutes to the campus' main gate.
- HUJI shuttle service: the service is available only during the academic year, on days when classes are held.
Additional information about public transportation in Jerusalem: The Jerusalem bus map