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The Alexander Silberman Institute of Life Science
Sperling Ruth
Prof. (Emeritus) Ruth Sperling
Structure and Function of the Nuclear Pre-mRNA Processing Machine
Genetics
Personal Information
Research Interests
Structure and function of the nuclear pre-mRNA processing machine. Pre-mRNA splicing. Pre-mRNA processing. Regulation of gene expression in eukaryotes. Assembly and structural studies of biological systems. Autoantibodies against nuclear RNPs-probes for inflammatory myopathies and RNA processing. Physical biochemistry. Electron microscopy.
Dissertation Topics
1. The endogenous spliceosome – structure and function in controlling posttranscriptional gene expression.
2. A new quality control mechanism within the endogenous spliceosome.
3. Small non-coding RNA as novel regulators of RNA processing and splicing.
4. Nuclear microRNA in cancer.
