In our lab we aim to study the process of oocyte development from germ stem cells. In our studies we make use of novel techniques we develop like: 1. CRISPR/Cas9 genome engineering and related manipulations. 2. Single oocyte transcriptome analysis. Our long term goal is to study these processes so we could understand the reasons for the decline in human oocyte quality, which leads to exponential increase in birth defects before a woman turns 40.