As a Systems Biology lab we combine experiments and theory to understand the design principles of biological networks: 1) Computation and functional dynamics in neural circuits with a single neuron resolution. 2) Plasticity in neural networks (Learning and memory, aging, neurodegenerative diseases) 3) Phenotypic variability: from gene expression and neural activity to behavior 4) Evolutionary and functional genomics: Transcription networks and the relationship between gene expression and genome structure.