Genetic Regulation of CNS Development & Neurodegenerative Diseases
Cell & Developmental Biology
Characterizing of the importance and function of bHLH transcription factors during the development of the embryonic nervous system (e.g. the cerebellum, Parkinson’s-related dopaminergic neurons and the spinal cord), using genetically engineered mice and chick embryos.
Discovering the molecular mechanism through which bHLH transcription factors act.
Applying the knowledge on normal embryonic development t to direct the fate of stem cells (as a tool for treating diseases like Parkinson’s).
Identification and study of disease caused by mutations in bHLH transcription factors.