Experimental Biology of Vertebrate Aging & Age-Related Diseases
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The molecular basis of aging, longevity, and age-related diseases.
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Identifying novel genes involved in cellular and organismal aging.
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Developing the turquoise killifish, the shortest-lived vertebrate, as a genetic model for experimental aging.
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Applying cutting-edge molecular and genomic approaches in the killifish and human cells (such as single-cell RNA-seq, CRISPR screens, Mass-spectrometry).
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Modeling age-associated diseases (e.g. neurodegeneration, decline in immune function) in the turquoise killifish using CRISPR/Cas9 genome editing.
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Live-imaging of aging-related process by generating fluorescent transgenic killifish.
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Exploring the effect of early life-history traits, such as age at sexual maturity, on the rate of aging.
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