Dissertation Topics

Dr. Itamar Harel
Experimental Biology of Vertebrate Aging & Age-Related Diseases
  1. The molecular basis of aging, longevity, and age-related diseases.
  2. Identifying novel genes involved in cellular and organismal aging.
  3. Developing the turquoise killifish, the shortest-lived vertebrate, as a genetic model for experimental aging.
  4. Applying cutting-edge molecular and genomic approaches in the killifish and human cells (such as single-cell RNA-seq, CRISPR screens, Mass-spectrometry).
  5. Modeling age-associated diseases (e.g. neurodegeneration, decline in immune function) in the turquoise killifish using CRISPR/Cas9 genome editing.
  6. Live-imaging of aging-related process by generating fluorescent transgenic killifish.
  7. Exploring the effect of early life-history traits, such as age at sexual maturity, on the rate of aging.