Speaker: Prof. Karen Avraham, Gray Faculty of Medical & Health Sciences, TAU
Title: Gene Discovery and Therapy for Deafness: Advances and Challenges
Speaker: Phd Liat Morciano, Prof Giora Simchen's and Prof Ayelet Arbel's Lab, HUJI
Title: Enhanced mutagenicity in yeast meiosis resulting from DNA repair
The Seminar Will be in Hebrew
Speaker: Dr. Leonid Peshkin, Systems Biology, Harvard Medical School
Title: From Frog Pond to Clinic: Characterizing Elusive Disease-Causing Proteins and Cells
Abstract: A fundamental challenge in biomedicine is the existence of "missing" proteins—predicted by the genome but elusive in human tissue samples, potentially hiding key mechanisms of disease. To solve this, we require not just a catalog of molecules, but an organized "periodic table" of cell types, mapping their molecular identities across development to pinpoint where and when these proteins function. Leveraging the experimental power of the Xenopus frog, we have built the foundation for such a resource. We first performed a comprehensive proteomic analysis of 25 adult tissues, quantifying over 15,000+ proteins to define tissue-specific expression patterns and identify conserved and missing proteins. To complement this, we have constructed a comprehensive single-cell transcriptomic atlas spanning embryonic development and the adult organism, providing a systematic classification of cell types and states. This integrated map allows us to move from simply observing protein presence to understanding their cellular origin. Our future work will leverage this foundational atlas to characterize, at single-cell resolution, the phased emergence of the immune system in the developing frog. This focused effort will directly illuminate the cellular context of elusive immunoregulatory proteins, bridging a critical gap between early development and adult function. Referencing this resource we aim to identify tangible targets for clinical insight.
Speaker: Mr. Guy Haim, Prof. Benvenisty Nissim's Lab, HUJI.
Title: Studying Polyploidy and Tumorigenicity using Human Embryonic Stem Cells
Speaker:Ms. Alana Amelan, Prof. Sagiv Shifman's Lab
Title: Knockout screens reveal genes essential for neuronal differentiation and implicate PEDS1 in neurodevelopment
Speaker: Dr. Kara Brenstein, University of Pennsylvania
Title: Finding Significance: Functional insights into homologous recombination deficient tumors through variant analysis
Speaker: Prof. Steven Schiff, Yale
Title: Neonatal Paenibacilliosis – Discovery of a highly lethal, neurotropic, environmentally driven disease of African neonates
Speaker: Prof. Erez Lieberman Aiden, Baylor College of Medicine
Title: Fossils of Ancient Chromosomes
Speaker: Dr. Shay Stern, Biology Faculty, Technion
Title: TBA
Speaker: Prof. Masha Niv, Faculty of Agriculture, Food and Environment, HUJI
Title: Bitter taste GPCRs in health and disease