Biological Chemistry

The research carried out in our department aims at understanding the mechanisms involved in the recognition and processing of information by individual cells, in health and in stress or disease states. The underlying theme of our studies involves the structure and function of proteins that communicate with the environment, under normal and abnormal conditions. The topics of our various research groups range from neuronal function and signaling in behavior and in neurodegeneration, through circadian rhythms, to the balance between death and proliferation in cancer cells. Some of our groups focus on signal transduction from the cell membrane, through the cytoplasm, to the nucleus. Other groups study the transcriptional and post-transcriptional changes in gene expression that result from such nuclear signaling. Additional groups focus on investigating the links between protein structure and function, how this information can be exploited to modify protein characteristics, and how cells meticulously maintain the quality of their proteins.
Our researchers use a plethora of experimental approaches, from bacteria, yeast, insect and mammalian systems, to genetically manipulated mouse models (transgenic mice, knock-out and knock-in), and recently-developed techniques such as lentiviral infection and RNA interference. State-of-the-art equipment is employed in our studies, and includes X-ray crystallography, mass-spectroscopy, confocal microscopy, and high throughput robotic screening.
The department's strength stems from the interdisciplinary approach that we apply to the questions at hand, and our ability to merge classic biochemistry with modern fields such as systems biology and computational biology.
 

E-mail Phone Fax Office
Prof. Julia Shifman Prof. Julia Shifman
Head of Department
02-65-84078 Silberman -525
Prof. Tomer Ravid Prof. Tomer Ravid
Head of Graduate Program
02-65-84349 Silberman -523
Ms. Ruth Mualem
Head of Secretariat
02-65-86447 Silberman 1-4XX
Ms. Drorit Ben-Haim
Secretariat Staff
02-65-85463 Silberman -4XX

2019

Time & Location Info
Thursday, June 20, 2019 - 12:00

Faculty Club, Silberman Bldg.

Speaker: Prof. Susan Greenfield

Title: A novel approach to neurodegeneration

Thursday, June 13, 2019 - 12:00

Faculty Club, Silberman Bldg.

Speaker: Prof. Etana Padan,Department of Biological Chemistry, Hebrew University of Jerusalem

Title: The NhaA Na+/H+ antiporter, new insight into structural and functional dynamics.

 
Thursday, June 6, 2019 - 12:00

Faculty Club, Silberman Bldg.

Speaker: Navit Mooshayef  under supervision of Prof. David Engelberg, HUJI

Title: An odd tale of p38 MAPK: from in vitro autophosphorylation to muscle differentiation

 
Thursday, May 30, 2019 - 12:00

Faculty Club, Silberman Bldg.

Speaker: Prof. Nathalie Q. Balaban, Physics Department, HUJI

Title: Evolution under intermittent antibiotic treatment

 
Thursday, May 23, 2019 - 12:00

Faculty Club, Silberman Bldg.

Speaker: Prof. Doron Gerber, Bar Ilan University

Title: Integrated  microfluidic interfaced for biochemistry

 
Thursday, May 16, 2019 - 12:00

Faculty Club, Silberman Bldg.

Speaker: Prof. Eitan Bibi, Weizmann Institute of Science

Title: Membrane protein biogenesis: a linkage between translation of the SRP receptor and membrane associated ribosomes

 
Thursday, May 2, 2019 - 12:00

Faculty Club, Silberman Bldg.

Speaker: Prof. Michal Sharon, Weizmann Institute of Science

Title: Specific regulation of a protein degradation pathway

 
Thursday, April 11, 2019 - 12:00

Faculty Club, Silberman Bldg.

Speaker: Prof. Elisha Haas, Bar Ilan University

Title: Nature’s shortcut to protein folding

 
Wednesday, April 10, 2019 - 13:00

Room 508, Silberman Bldg.

Speaker: Juana Bana, HUJI

Title: Young Biochemistry and Cell

Wednesday, April 10, 2019 - 12:00

Faculty Club, Silberman Bldg.

Speaker: Prof. Nikolay Dokholyan, Penn State University

Title: Molecular Design for Research and Therapeutics

 
Thursday, April 4, 2019 - 12:00

Faculty Club, Silberman Bldg.

Speaker: Prof. Michael Berger, Faculty of Medicine, HUJI

Title: Mitochondrial matrix compartment energetics limits hypoxia tolerance during CD8 T cell priming

 
Monday, April 1, 2019 - 10:00

Faculty Club, Silberman Bldg.

Speaker: Prof. Michael H. Hecht, Princeton University

Title: Sustaining life with genes and proteins designed from scratch (Special Seminar)

 
Thursday, March 28, 2019 - 12:00

Faculty Club, Silberman Bldg.

Speaker: Prof. Alex Rouvinski, School of Medicine, The Hebrew University

Title: Virus host interactions in insect-borne and insect restricted arboviruses

 
Tuesday, March 26, 2019 - 12:00

Faculty Club, Silberman Bldg.

Speaker: Dr. Tami Geiger,Department of Human Molecular Genetics and BiochemistrySackler Faculty of Medicine,Tel Aviv University

Title: Proteomic analysis of melanoma response to immunotherapy

 

 

Thursday, March 14, 2019 - 12:00

Faculty Club, Silberman Bldg.

Speaker: Prof. Asya Rolls,Technion

Title: The bi-directional communication between the brain and the immune system

 
Thursday, January 17, 2019 - 12:00

Faculty club, Silberman bldg.

Speaker: Dr. Nir London, Department of Organic Chemistry, Weizmann Institute of Science

Title: Computational and experimental covalent ligand discovery

 
Thursday, January 10, 2019 - 12:00

Faculty club, Silberman bldg.

Speaker: Prof. Shu Quan, East China University of Science and Technology, Shanghai, China

Title: Spy-ing into protein stability in vivo

2018

Time & Location Info
Thursday, December 13, 2018 - 12:00

Faculty club, Silberman bldg.

Speaker: Prof. Shimon Weiss, Department of Chemistry & Biochemistry, UCLA

Title: TBA

Thursday, November 22, 2018 - 12:00

Faculty club, Silberman bldg.

Speaker: Prof. David Lukatsky Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva

Title: DNA SEQUENCE REPEAT SYMMETRY DETERMINES TRANSCRIPTION FACTOR BINDING IN EMBRYONIC STEM CELLS

Thursday, November 15, 2018 - 12:00

Faculty club, Silberman bldg.

Speaker: Prof. Ronen Berkovich, Ben-Gurion University of the Negev 

Title: Determination of EspA protein mechanical properties using AFM based single molecule force spectroscopy 

Thursday, November 8, 2018 - 12:00

Faculty club, Silberman bldg.

Speaker: Prof. Oded Lewinson, Technion
Title: Structural dynamics of ABC transporters 

Sunday, January 21, 2018 - 09:00 to 10:00

Faculty club, Silberman bldg.

Speaker: Dr. Rahpael Alhadeff Dept. of Chemistry University of Southern California (Candidate seminar)

Title: Generating energy landscapes and using them to study complex biological systems

 

 

 

Ms. Evrim Servili
Prof. Etana Padan
Prof. Ioav  Cabantchik
Prof. Nir Friedman
Prof. Etana Padan
Prof. Hermona Soreq
Prof. Hermona Soreq
Prof. Alex Levitzki
Mr. Alon Appleboim
Ms. Yifat Geffen
Ms. Dana Yaffe
Dr. Oren Ram
Dr. Dana Reichmann
Prof. Shy Arkin
Professor Michal Linial
Dr. Dana Reichmann
Prof. Ioav  Cabantchik
Dr. Ami Citri
Prof. Hermona Soreq
Prof. Nir Friedman
Prof. Alex Levitzki
Prof. Nir Friedman
Prof. Alex Levitzki
Prof. Hermona Soreq
Prof. Nir Friedman
Prof. Hermona Soreq
Prof. Shy Arkin
Prof. Avraham Hochberg
Prof. Alex Levitzki
Prof. Daphne Atlas
Prof. Hermona Soreq
Prof. Nir Friedman
Prof. Alex Levitzki
Prof. Zvi Selinger
Prof. Zvi Selinger
Prof. Hermona Soreq
Prof. Nir Friedman
Mr. Erez Podoly
E-mail Phone Fax Office
Mr. Alon Appleboim Mr. Alon Appleboim

02-65- Silberman 2-3XX
Prof. Shy Arkin Prof. Isaiah (Shy) Arkin

Research website
02-65-84329 02-6584329 Silberman -527
Prof. Daphne Atlas Prof. (Emeritus) Daphne Atlas

02-65-85406 Silberman -607
Ms. Orly Avraham

02-65-86894 Silberman 1-6xx
Ms. Juana Bana

02-65- Silberman 1-633
Ms. Drorit Ben-Haim

02-65-85463 Silberman -4XX
Dr. Ester Bennett

02-65-85431 Silberman 1-4XX
Prof. Ioav  Cabantchik Prof. (Emeritus) Ioav Cabantchik

972-765407656 972-765407656
Dr. Ami Citri Dr. Ami Citri

Research Website
02-65-84978
Dr. Tsiona Eliyahu

02-65-889 02-6586448 1-5XX
Prof. David Engelberg Prof. David Engelberg

02-65-84718 02-6586448 Silberman -517
Prof. Nir Friedman Prof. Nir Friedman

Research website
02-5494557 Silberman -313
Ms. Yifat Geffen Ms. Yifat Geffen

02-65-86012 Silberman 1-523
Prof. Hagai Ginsburg Prof. (Emeritus) Hagai Ginsburg

MPMP
02-65-
Dr. Nir Kalisman Dr. Nir Kalisman

Research website
02-65-84487 Silberman -451
Dr. Shoshana Klein

02-65-85401 Silberman 1-6xx
Ms. Miriam Krugliak

02-65-85194 Silberman 1-5XX
Prof. Emeritus Richard Kulka Prof. (Emeritus) Richard Kulka

02-65-
Prof. (Emeritus) Yehuda Lapidot

02-65-
Dr. Eitan Lerner Dr. Eitan Lerner

Research website
02-65-85457 Silberman 1-435
Prof. Alex Levitzki Prof. (Emeritus) Alex Levitzki

Research website
02-65-85404 Silberman -644
Professor Michal Linial Prof. Michal Linial

02-65-85425 Silberman -515
Prof. Oded Livnah Prof. Oded Livnah

02-65-86894 02-6585573 Wolfson -10
Prof. Emeritus Abraham Loyter Prof. (Emeritus) Abraham Loyter

02-65-85422 Silberman -625
Ms. Ruth Mualem

02-65-86447 Silberman 1-4XX
Prof. Orly Prof. (Emeritus) Joseph Orly

02-65-85451 02-6586448 Silberman -431
Prof. Etana Padan Prof. (Emeritus) Etana Padan

02-65-85094 Silberman 1-335
Dr. Ayelet Rahat

02-65-84295 Silberman 2-3XX
Dr. Oren Ram Dr. Oren Ram

Research website
02-65-85408 Silberman -611
Prof. Tomer Ravid Prof. Tomer Ravid

Research website
02-65-84349 Silberman -523
Dr. Dana Reichmann Dr. Dana Reichmann

Research website
02-65-86952 02-658-6448 Silberman -637
Dr. Dina Schneidman Dr. Dina Schneidman

Research website
02-65-85423 Silberman 1-513
Prof. Shimon Schuldiner Prof. (Emeritus) Shimon Schuldiner

Research website
02-65-85992 Silberman 1-339
Ms. Evrim Servili Ms. Evrim Servili

02-65-85402 Silberman 1-6XX
Prof. Julia Shifman Prof. Julia Shifman

02-65-84078 Silberman -525
Prof. Hermona Soreq Prof. (Emeritus) Hermona Soreq

Research website
02-65-85109 02-652 0258 Silberman -420
Prof. Emeritus Zeev Stein Prof. (Emeritus) Zeev Wilfred Stein

02-65-
Dr. Moshe (Michael) Trus

02-65-85402 Silberman 1-6XX